![]() ![]() Visual evaluation was performed using 3D image reconstructions all measurements were performed on 2D multi-planar reconstructions of the 3D datasets. Both radiologists were blinded to image acquisition methods and intracranial pathologies. Image evaluation was performed separately and independently by two experienced radiologists on standard post-processing Picture Archiving and Communcation system (PACS) workstations (Centricity RIS 4.0i, GE Healthcare, USA). A total of 20 intracranial aneurysms were detected, with two patients showing multiple aneurysms (2, respectively 4 aneurysms). The following sequences were obtained: (1) 7 Tesla TOF MRA, (2) 1.5 Tesla TOF MRA and (3) 7 Tesla non-contrast enhanced MPRAGE. All patients were accordingly examined at a 7 Tesla (Magnetom 7T, Siemens) and a 1.5 Tesla MR scanner system (Espree, Siemens) utilizing dedicated head coils. ![]() Exclusion criteria were: 1) cardiac pacemakers or any other electronic implants, 2) metallic implants, 3) pregnancy or breast feeding period, 4) claustrophobia and 5) chronic or episodic vertigo. Inclusion criteria were: 1) single or multiple UIA, 2) age 18–80 years, 3) ability to give informed consent and 4) legal competence. The study group comprised 16 neurosurgical patients (male n = 5, female n = 11, average age 53.38 years range 38–70 years). This prospective study evaluates the diagnostic ability of 7 Tesla TOF MRA in comparison to 1.5 Tesla TOF MRA and 7 Tesla non-contrast enhanced MPRAGE for delineation of UIA. The purpose of this prospective study was to evaluate the image quality and diagnostic ability in the assessment of UIA of 1.5 Tesla TOF MRA in comparison to ultra-high-field TOF MRA and non-enhanced MPRAGE imaging. The increase of the magnetic field strength from 1.5 to 3 Tesla, and respectively to 7 Tesla, allowed for a successful transition of the increased signal-to-noise (SNR) and contrast-to-noise ratio (CNR) to improvements in spatial resolution and vessel contrast. With the successful introduction of (ultra-) highfield non-enhanced MRA of the intracranial vasculature, recent studies performed at 3 and 7 Tesla reported improved depiction of UIA with sensitivity rates comparable to the gold standard DSA –. Within the past 15 years, 1.5 Tesla magnetic resonance angiography (MRA) has evolved to become an excellent non-invasive diagnostic alternative to DSA, yielding sensitivity rates of 79–97% for the detection of small UIA –. Nevertheless, due to the application of ionizing radiation and iodinated contrast agent as well as the general risk affiliated to invasive interventional procedures, DSA is associated with a 0.2%–0.5% risk for severe permanent neurological complications. ĭigital subtraction angiography (DSA) is considered the gold standard for detection of UIA. Size and shape of unruptured intracranial aneurysms (UIA) are known to be significantly affiliated with rupture rates, hence, high-quality assessment of UIA and its related features displays an important role on potential aneurysm treatment –. Rupture of intracranial aneurysm is associated with high morbidity and mortality rates, as it is known to be accountable for 80% of all subarachnaoid hemorrhages (SAH), causing 25% of all cerebrovascular-related deaths. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. ![]() This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: An IFORES grant to KHW from the University Duisburg-Essen supported the research. Received: AugAccepted: NovemPublished: January 6, 2014Ĭopyright: © 2014 Wrede et al. PLoS ONE 9(1):Įditor: Zhuoli Zhang, Northwestern University Feinberg School of Medicine, United States of America (2014) Non-Enhanced MR Imaging of Cerebral Aneurysms: 7 Tesla versus 1.5 Tesla. Citation: Wrede KH, Dammann P, Mönninghoff C, Johst S, Maderwald S, Sandalcioglu IE, et al. ![]()
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